Try out PMC Labs and tell us what you think. Learn More. Orofacial or tardive dyskinesias are involuntary repetitive movements of the mouth and face. In most cases, they occur in older psychotic patients who are in institutions and in whom long-term treatment with antipsychotic drugs of the phenothiazine and butyrophenone groups is being carried out.
Spontaneous Oral-Facial Dyskinesia
Spontaneous Oral-Facial Dyskinesia | JAMA Neurology | JAMA Network
Orofacial movement disorders OMD are a group of conditions that affect the motor aspect of the trigeminal, facial, and hypoglossal cranial nerves. These alterations are produced by pathologic disorders affecting the central nervous system, manifesting as isolated or combined hyperkinetic dysfunctional activities on the masticatory, facial mimic, or tongue musculatures. A comprehensive understanding of orofacial dystonias is essential to identify different variants of OMD that could be easily mislabeled or misdiagnosed. In this chapter, the authors focus on different aspects of the pathophysiology, epidemiology, clinical features, and management of orofacial dystonias and other movement disorders that are poorly recognized but not uncommon presentations of OMD, such as orofacial dyskinesias, drug-induced orofacial reactions, tardive orofacial syndromes, and bruxism.
Oral-facial dyskinesia is not uncommonly encountered as side-effect of chronic phenothiazine treatment or levodopa therapy, is less commonly seen during the course of known hereditary or acquired basal ganglia diseases, and is rarely seen under other circumstances. Two cases of spontaneous oral-facial dyskinesia are described. The pathology and pathophysiology of this type of involuntary movement disorder are unknown, and the prognosis is uncertain.
Metrics details. Here, we report the case of late-onset oro-facial dyskinesia in an elderly patient with a genetic diagnosis of Spinocerebellar Ataxia type 2 SCA2. No exposure to anti-dopaminergic agents, other neuroleptics, antidepressants, or other drugs was reported. Family history was positive for SCA2 brother and the son of the brother.